Ro 26-4550 trifluoroacetate

Name: Ro 26-4550 trifluoroacetate
Brand: Tocris Bioscience
SKU: 1794

Cat. No. 1794 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1794 has been discontinued.

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说明： Competitive inhibitor of IL-2/ IL-2Rα receptor interaction

化学名： N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Ro 26-4550 trifluoroacetate

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC₅₀ = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

技术数据 for Ro 26-4550 trifluoroacetate

分子量	560.57
公式	C₂₆H₃₀N₄O₃.CF₃CO₂H
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	1217448-66-2
PubChem ID	16760522
InChI Key	BVMWPONRCOSTMK-RFPXDPOKSA-N
Smiles	FC(F)(F)C(O)=O.NC(N1CCC[C@H](CC(N[C@H](C(OC)=O)CC2=CC=C(C#CC3=CC=CC=C3)C=C2)=O)C1)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ro 26-4550 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ro 26-4550 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Braisted et al (2003) Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 125 3714 PMID: 12656598

Tilley et al (1997) Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc. 119 7589

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