Ro 48-8071 fumarate

Cat. No. 5389 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis

化学名： (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ro 48-8071 fumarate

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC₅₀ = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC₅₀ = 1.74 μM).

化合物库 for Ro 48-8071 fumarate

Ro 48-8071 fumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ro 48-8071 fumarate

分子量	564.44
公式	C₂₃H₂₇BrFNO₂.C₄H₄O₄
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	189197-69-1
PubChem ID	9959583
InChI Key	XCYAYLWZCRGKDS-WLHGVMLRSA-N
Smiles	FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 48-8071 fumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	11.29	20 温和加热
	DMSO	56.44	100

制备储备液 for Ro 48-8071 fumarate

以下数据基于产品分子量 564.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.86 mL	17.72 mL
5 mM	0.35 mL	1.77 mL	3.54 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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产品说明书 for Ro 48-8071 fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ro 48-8071 fumarate

参考文献是支持产品生物活性的出版物。

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 38 373 PMID: 9162756

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171

If you know of a relevant reference for Ro 48-8071 fumarate, please let us know.

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