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Submit ReviewRo 64-5229
说明： Selective, non-competitive mGlu2 antagonist
化学名： (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
纯度： ≥99% (HPLC)
生物活性 for Ro 64-5229
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).
化合物库 for Ro 64-5229
Ro 64-5229 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Ro 64-5229
| 分子量 | 352.26 |
| 公式 | C17H19Cl2N3O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 246852-46-0 |
| PubChem ID | 10428048 |
| InChI Key | STCVFKBRXOEQRF-YBEGLDIGSA-N |
| Smiles | ClC1=CC=CC(Cl)=C1/C(OC3CCCCCC3)=C/N2N=CN=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ro 64-5229
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.23 | 100 | |
| ethanol | 35.23 | 100 |
制备储备液 for Ro 64-5229
以下数据基于产品分子量 352.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.39 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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产品说明书 for Ro 64-5229
参考文献 for Ro 64-5229
参考文献是支持产品生物活性的出版物。
Kolczewski et al (1999) Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 9 2173 PMID: 10465539
Brauner-Osbourne et al (2007) Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 8 169 PMID: 17266540
If you know of a relevant reference for Ro 64-5229, please let us know.
关键词: Ro 64-5229, Ro 64-5229 supplier, Ro64-5229, mGluR2, mGlu2, group, II, metabotropic, glutamate, receptor, antagonist, antagonists, Glutamate, (Metabotropic), Group, Receptors, 2913, Tocris Bioscience
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