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Submit ReviewRO 8191
说明： IFNα receptor 2 agonist
化学名： 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine
纯度： ≥98% (HPLC)
生物活性 for RO 8191
RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.
技术数据 for RO 8191
| 分子量 | 373.22 |
| 公式 | C14H5F6N5O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 691868-88-9 |
| PubChem ID | 2768133 |
| InChI Key | GRHYZVJEXKTJOS-UHFFFAOYSA-N |
| Smiles | FC(F)(C1=CC(C(F)(F)F)=C2C=CC3=NC(C4=NN=CO4)=CN3C2=N1)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RO 8191
参考文献 for RO 8191
参考文献是支持产品生物活性的出版物。
Konishi et al (2012) An orally available, small-molecule interferon inhibits viral replication. Sci.Rep. 2 PMID: 22355771
Zheng et al (2021) Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Ann.Transl.Med. 9 PMID: 34268416
Furutani et al (2019) An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One 14 PMID: 31188831
Ishibashi et al (2019) Type I interferon protects neurons from prions in in vivo models. Brain 142 PMID: 30753318
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关键词: RO 8191, RO 8191 supplier, RO8191, IFNAR2, receptor, agonist, phosphorylates, IFNalpha, interferon, alpha, IFN-alpha, Cytokine, Receptors, Hepatitis, Viruses, Prion, Protein, 7375, Tocris Bioscience
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