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Submit ReviewRopinirole is a selective D2-like receptor agonist (D3 > D2 > D4). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays anti-Parkinsonian activity.
分子量 | 296.84 |
公式 | C16H24N2O.HCl |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 91374-20-8 |
PubChem ID | 68727 |
InChI Key | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
Smiles | O=C2NC1=CC=CC(CCN(CCC)CCC)=C1C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 29.68 | 100 | |
DMSO | 14.84 | 50 |
以下数据基于产品分子量 296.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.37 mL | 16.84 mL | 33.69 mL |
5 mM | 0.67 mL | 3.37 mL | 6.74 mL |
10 mM | 0.34 mL | 1.68 mL | 3.37 mL |
50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
参考文献是支持产品生物活性的出版物。
Eden et al (1991) Preclinical pharmacology of ropin. (SK&F 101468-A) a novel DA D2 agonist. Pharmacol.Biochem.Behav. 38 147 PMID: 1673248
Tulloch (1997) Pharmacologic profile of ropinirole: a nonergoline DA agonist. Neurology 49 S58 PMID: 9222275
If you know of a relevant reference for Ropinirole, please let us know.
关键词: Ropinirole, Ropinirole supplier, Selective, D2-like, agonists, non-selective, dopamine, receptors, dopaminergic, Non-selective, Dopamine, 3680, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Ropinirole 的部分引用包括:
Stefan et al (2021) New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling. Sci Rep 11 8288 PMID: 33859231
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.