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Rosuvastatin calcium

Cat. No. 6343 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent HMG-CoA reductase inhibitor
化学名： (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Rosuvastatin calcium

Rosuvastatin calcium is a potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Enhances lentiviral transduction of natural killer cells. Orally bioavailable.

化合物库 for Rosuvastatin calcium

Rosuvastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Rosuvastatin calcium

分子量 500.57
公式 C22H27FN3O6S.½Ca
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 147098-20-2
PubChem ID 5282455
InChI Key LALFOYNTGMUKGG-BGRFNVSISA-L
Smiles CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rosuvastatin calcium

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.06 100

制备储备液 for Rosuvastatin calcium

以下数据基于产品分子量 500.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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产品说明书 for Rosuvastatin calcium

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Rosuvastatin calcium

参考文献是支持产品生物活性的出版物。

McTaggart et al (2001) Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 87 28B PMID: 11256847

Gong et al (2020) Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor. Mol.Ther.Methods Clin.Dev. 17 634 PMID: 32300610

If you know of a relevant reference for Rosuvastatin calcium, please let us know.

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关键词: Rosuvastatin calcium, Rosuvastatin calcium supplier, ZD4522, HMG, CoA, reductase, inhibitors, inhibits, statins, 3-hydroxy-3-methyl-glutaryl-CoA, orally, bioavailable, viral, transduction, enhancers, enhances, HMG-CoA, Reductase, Viral, Transduction, Enhancers, 6343, Tocris Bioscience

1 篇 Rosuvastatin calcium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rosuvastatin calcium 的部分引用包括：

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942

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