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Roxindole hydrochloride

Cat. No. 1559 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1559 has been discontinued.

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说明： Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
别名： EMD 49980
化学名： 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
纯度： ≥98% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Roxindole hydrochloride

Roxindole hydrochloride is a dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

技术数据 for Roxindole hydrochloride

分子量 382.93
公式 C23H26N2O.HCl
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 108050-82-4
PubChem ID 9886286
InChI Key ZCEPVNSWLLJECX-UHFFFAOYSA-N
Smiles OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Roxindole hydrochloride

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参考文献 for Roxindole hydrochloride

参考文献是支持产品生物活性的出版物。

Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a DA D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41 PMID: 8558454

Newman-Tancredi et al (1999) Actions of roxindole at recombinant human DA D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447 PMID: 10431754

Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 DA agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31 PMID: 2565817

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