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RS 1

Cat. No. 5810 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5810 has been discontinued.

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说明： High affinity RAD51 activator; also CRISPR enhancer
化学名： 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for RS 1

RS 1 is a high affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

技术数据 for RS 1

分子量 524.23
公式 C20H16Br2N2O3S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 312756-74-4
PubChem ID 1039737
InChI Key SWKAVEUTKGKHSR-UHFFFAOYSA-N
Smiles BrC1=CC=C(C=C1)NC(C2=CC=C(C(S(=O)(NCC3=CC=CC=C3)=O)=C2)Br)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for RS 1

参考文献是支持产品生物活性的出版物。

Song et al (2016) RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat.Commun. 7 10548 PMID: 26817820

Jayathilaka et al (2008) A chemical compound that stimulates the human homologous recombination protein RAD51. Proc.Natl.Acad.Sci.U.S.A. 105 15848 PMID: 18840682

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关键词: RS 1, RS 1 supplier, RS1, high, affinity, RAD51, activators, homologous, recombination, DNA, during, double, strand, break, repair, CRISPR, HDR, homology-directed, DNA,, RNA, and, Protein, Synthesis, Reagents, 5810, Tocris Bioscience

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