RS 25344 hydrochloride

Name: RS 25344 hydrochloride
Brand: Tocris Bioscience
SKU: 3315

Cat. No. 3315 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3315 has been discontinued.

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说明： Potent PDE4 inhibitor

化学名： 1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for RS 25344 hydrochloride

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC₅₀ values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

技术数据 for RS 25344 hydrochloride

分子量	411.8
公式	C₁₉H₁₃N₅O₄.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	152815-28-6
PubChem ID	19781728
InChI Key	ROSFKXDQMBPYQQ-UHFFFAOYSA-N
Smiles	O=C(N(CC4=CC=NC=C4)C2=O)N(C3=CC([N+]([O-])=O)=CC=C3)C1=C2C=CC=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RS 25344 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RS 25344 hydrochloride

参考文献是支持产品生物活性的出版物。

Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616 PMID: 7476886

Kaneko et al (1995) Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell.Signal. 7 527 PMID: 8562314

Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109 PMID: 16177223

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关键词: RS 25344 hydrochloride, RS 25344 hydrochloride supplier, RS25344, potent, PDE4, inhibitors, inhibits, phosphodiesterases, Phosphodiesterases, 3315, Tocris Bioscience

1 篇 RS 25344 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RS 25344 hydrochloride 的部分引用包括：

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Cell Rep 171 2385 PMID: 24467222