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Submit ReviewRS 56812 hydrochloride
说明： 5-HT3 partial agonist
化学名： (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for RS 56812 hydrochloride
RS 56812 hydrochloride is a highly potent and selective 5-HT3 partial agonist, with a pKi at 5-HT3 receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.
许可信息
Sold with the permission of Roche Bioscience
技术数据 for RS 56812 hydrochloride
| 分子量 | 347.84 |
| 公式 | C18H21N3O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 143339-12-2 |
| PubChem ID | 67858205 |
| InChI Key | NHWCYXITJPBOHX-RSAXXLAASA-N |
| Smiles | O=C(C(N[C@@H]3C(CC4)CCN4C3)=O)C1=CN(C)C2=C1C=CC=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RS 56812 hydrochloride
参考文献 for RS 56812 hydrochloride
参考文献是支持产品生物活性的出版物。
Clark et al (1995) N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg.Med.Chem.Lett. 5 1853
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关键词: RS 56812 hydrochloride, RS 56812 hydrochloride supplier, 5-HT3, partial, agonists, Serotonin, Receptors, RS56812, hydrochloride, 0988, Tocris Bioscience
1 篇 RS 56812 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RS 56812 hydrochloride 的部分引用包括：
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry 7 2336 PMID: 26114334
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.