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说明： Potent NMDA antagonist
化学名： (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
技术数据 for (RS)-CPP
| 分子量 | 252.21 |
| 公式 | C8H17N2O5P |
| 储存 | Desiccate at RT |
| CAS Number | 100828-16-8 |
| PubChem ID | 1228 |
| InChI Key | CUVGUPIVTLGRGI-UHFFFAOYSA-N |
| Smiles | O=C(C1NCCN(CCCP(O)(O)=O)C1)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (RS)-CPP
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.22 | 100 |
制备储备液 for (RS)-CPP
以下数据基于产品分子量 252.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.82 mL | 39.65 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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产品说明书 for (RS)-CPP
参考文献 for (RS)-CPP
参考文献是支持产品生物活性的出版物。
Davies et al (1986) CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]-D-AP5 binding sites on brain membranes and anti-convulsant activity. Brain Res. 382 169 PMID: 2876749
If you know of a relevant reference for (RS)-CPP, please let us know.
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关键词: (RS)-CPP, (RS)-CPP supplier, Potent, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0173, Tocris Bioscience
34 篇 (RS)-CPP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (RS)-CPP 的部分引用包括：
Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753
Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Eur J Neurosci 31 1219 PMID: 20345918
Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045
Gaier et al (2010) Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci 30 13656 PMID: 20943906
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
Chen et al (2018) In Vivo Regulation of Oligodendrocyte Precursor Cell Proliferation and Differentiation by the AMPA-Receptor Subunit GluA2. Cell Rep 25 852 PMID: 30355492
Armbruster et al (2014) Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion. Front Cell Neurosci 8 277 PMID: 25249939
Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636 PMID: 20384810
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
Maag et al (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Front Neurosci 9 351 PMID: 26483626
Neuner et al (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281 69 PMID: 25513972
Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits 7 179 PMID: 24273495
Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546
Pollak et al (2017) Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy. PLoS One 12 e0172884 PMID: 28264064
Toyoizumi et al (2014) Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron 84 497 PMID: 25374364
Vaghi et al (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb Cortex 24 1247 PMID: 23258346
Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148 PMID: 25165854
Viemari et al (2011) Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci 33 2228 PMID: 21615559
Voyer (2017) Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors Neuropharmacology 112 150 PMID: 27267684
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Elife 4 PMID: 25723967
Zhao et al (2015) Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. J Neurosci 35 308 PMID: 25568123
Ferreira et al (2015) Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. Front Cell Neurosci 9 161 PMID: 25972785
Hooks et al (2015) Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex. J Neurosci 35 4418 PMID: 25762684
Messer and Levine (2012) Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res 90 1454 PMID: 22388975
Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci 25 5502 PMID: 15944378
Ziskin et al (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 10 321 PMID: 17293857
Logan et al (2007) Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons. J Neurophysiol 98 2693 PMID: 17804581
Bloodgood and Sabatini (2007) Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron 53 249 PMID: 17224406
Abraham et al (2001) Heterosynaptic metaplasticity in the hippocampus in vivo: a BCM-like modifiable threshold for LTP. Proc Natl Acad Sci U S A 98 10924 PMID: 11517323
Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577 PMID: 8096780
Sacktor et al (1993) Persistent activation of the ζ isoform of protein kinase C in the maintenance of long-term potentiation. Proc Natl Acad Sci U S A 90 8342 PMID: 8378304
Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901 PMID: 16199519
Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551 PMID: 15140926
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Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
分析类型： In Vivo
种属： Mouse
CPP 5 mM
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