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Submit ReviewRU 58668
Discontinued Product
This product has been withdrawn from sale and is superseded by Endoxifen (Cat. No. 3705)
说明： Pure antiestrogen
化学名： (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol
纯度： ≥95% (HPLC)
生物活性 for RU 58668
Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
技术数据 for RU 58668
| 分子量 | 658.76 |
| 公式 | C34H43F5O5S |
| 储存 | Store at +4°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 151555-47-4 |
| PubChem ID | 6918261 |
| InChI Key | SDCUWFRXMLQNCS-LFAPAAFUSA-N |
| Smiles | OC1=CC=C2C(CC[C@]3([H])[C@@]([H])2[C@@H]([C@]5=CC=C(OCCCCCS(CCCC(F)(F)C(F)(F)F)(=O)=O)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RU 58668
参考文献 for RU 58668
参考文献是支持产品生物活性的出版物。
Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263 PMID: 9443403
Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449
Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in OE-dependent cancers. J.Steroid Molec.Biol. 92 1
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关键词: RU 58668, RU 58668 supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Estrogen, and, Related, Receptors, 3224, Tocris Bioscience
2 篇 RU 58668 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RU 58668 的部分引用包括：
Toy et al (2017) Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists. Cancer Discov 7 277 PMID: 27986707
Adurthi et al (2017) Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. Sci Rep 7 17289 PMID: 29229929
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