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RWJ 21757

Cat. No. 2719 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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2719 has been discontinued.

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说明： Toll-like receptor 7 (TLR7) agonist
别名： Loxoribine,7-Allyl-8-oxoguanosine
化学名： 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
纯度： ≥97% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for RWJ 21757

Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.

技术数据 for RWJ 21757

分子量 339.3
公式 C13H17N5O6
储存 Desiccate at +4°C
纯度 ≥97% (HPLC)
CAS Number 121288-39-9
PubChem ID 60737
InChI Key VDCRFBBZFHHYGT-IOSLPCCCSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C(N3CC=C)=O)C2=C3C(NC(N)=N2)=O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RWJ 21757

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参考文献 for RWJ 21757

参考文献是支持产品生物活性的出版物。

Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457 PMID: 7949100

Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987 PMID: 14579267

Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646 PMID: 12738885

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关键词: RWJ 21757, RWJ 21757 supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Loxoribine, 7-Allyl-8-oxoguanosine, Receptors, 2719, Tocris Bioscience

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Pathways for RWJ 21757

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.