RWJ 56110

Name: RWJ 56110
Brand: Tocris Bioscience
SKU: 2614

Cat. No. 2614 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2614 has been discontinued.

View all Protease-Activated Receptors products.

说明： Selective PAR₁ antagonist

化学名： (αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide

纯度： ≥96% (HPLC)

说明书

引用文献 (5)

生物活性技术数据说明书参考文献

生物活性 for RWJ 56110

RWJ 56110 is a selective protease-activated receptor-1 (PAR₁) antagonist; displays no activity at PAR₂, PAR₃, or PAR₄ subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo.

技术数据 for RWJ 56110

分子量	863.65
公式	C₄₁H₄₃Cl₂F₂N₇O₃.2HCl
储存	Store at -20°C
纯度	≥96% (HPLC)
CAS Number	2387505-58-8
PubChem ID	90488773
InChI Key	MGZSVSHDIOPSBO-ZEUUMAKDSA-N
Smiles	ClC1=CC=CC(Cl)=C1CN3C2=CC(NC(N[C@@H](CC5=CC(F)=C(F)C=C5)C(N[C@@H](CCN)C(NCC6=CC=CC=C6)=O)=O)=O)=CC=C2C(CN4CCCC4)=C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RWJ 56110

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RWJ 56110

参考文献是支持产品生物活性的出版物。

Maryanoff et al (2003) Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr.Med.Chem.Cardiovasc.Hematol.Agents 1 13 PMID: 15317288

Zania et al (2006) Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J.Pharmacol.Exp.Ther. 318 246 PMID: 16595737

Andrade-Gordon et al (1999) Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc.Natl.Acad.Sci.USA 96 12257 PMID: 10535908

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关键词: RWJ 56110, RWJ 56110 supplier, selective, PAR1, antagonists, PAR, receptors, protease-activated, proteinase-activated, RWJ56110, 252889-88-6, Protease-Activated, Receptors, 2614, Tocris Bioscience