RWJ 56110

Cat. No. 2614 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective PAR₁ antagonist

化学名： (αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide

纯度： ≥96% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RWJ 56110

RWJ 56110 is a selective protease-activated receptor-1 (PAR₁) antagonist; displays no activity at PAR₂, PAR₃, or PAR₄ subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo.

技术数据 for RWJ 56110

分子量	863.65
公式	C₄₁H₄₃Cl₂F₂N₇O₃.2HCl
储存	Store at -20°C
纯度	≥96% (HPLC)
CAS Number	2387505-58-8
PubChem ID	90488773
InChI Key	MGZSVSHDIOPSBO-ZEUUMAKDSA-N
Smiles	ClC1=CC=CC(Cl)=C1CN3C2=CC(NC(N[C@@H](CC5=CC(F)=C(F)C=C5)C(N[C@@H](CCN)C(NCC6=CC=CC=C6)=O)=O)=O)=CC=C2C(CN4CCCC4)=C3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RWJ 56110

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	21.59	25
	DMSO	86.36	100

制备储备液 for RWJ 56110

以下数据基于产品分子量 863.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.16 mL	5.79 mL	11.58 mL
5 mM	0.23 mL	1.16 mL	2.32 mL
10 mM	0.12 mL	0.58 mL	1.16 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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产品说明书 for RWJ 56110

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RWJ 56110

参考文献是支持产品生物活性的出版物。

Maryanoff et al (2003) Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr.Med.Chem.Cardiovasc.Hematol.Agents 1 13 PMID: 15317288

Zania et al (2006) Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J.Pharmacol.Exp.Ther. 318 246 PMID: 16595737

Andrade-Gordon et al (1999) Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc.Natl.Acad.Sci.USA 96 12257 PMID: 10535908

If you know of a relevant reference for RWJ 56110, please let us know.

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关键词: RWJ 56110, RWJ 56110 supplier, selective, PAR1, antagonists, PAR, receptors, protease-activated, proteinase-activated, RWJ56110, 252889-88-6, Protease-Activated, Receptors, 2614, Tocris Bioscience