S 107 hydrochloride

Name: S 107 hydrochloride
Brand: Tocris Bioscience
SKU: 3893

Cat. No. 3893 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3893 has been discontinued.

View all General Calcium Signaling Agents products.

说明： RyR1 stabilizer; inhibits Ca²⁺ leak from the SR

化学名： 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for S 107 hydrochloride

Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca²⁺ leak from the sarcoplasmic reticulum (SR). Activity results in improved muscle function and increased exercise performance in a Duchenne muscular dystrophy (DMD) mouse model (mdx). Also reduces exercise-induced muscle damage by lowering calpain activation and plasma creatine kinase levels.

技术数据 for S 107 hydrochloride

分子量	245.77
公式	C₁₁H₁₅NOS.HCl
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	927871-76-9
Smiles	CN2CCSC1=CC=C(OC)C=C1C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for S 107 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for S 107 hydrochloride

参考文献是支持产品生物活性的出版物。

Bellinger et al (2008) Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc.Natl.Acad.Sci. 105 2198

Bellinger et al (2009) Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle. Nature Med. 15 325

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篇 S 107 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 S 107 hydrochloride 的引用文献。