主页 / 药理学 / Enzymes / Demethylases / Histone Demethylases / Histone Demethylase Inhibitors / S 2101

S 2101

Cat. No. 5714 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： LSD1 inhibitor
化学名： (1R,2S)-rel-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cycloprpanamine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for S 2101

S 2101 is a LSD1 inhibitor (IC50 = 990 nM; Ki = 610 nM). Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).

技术数据 for S 2101

分子量 311.75
公式 C16H15F2NO.HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1239262-36-2
PubChem ID 121513887
InChI Key CTSUZAFTJVLOIX-SBKWZQTDSA-N
Smiles FC1=CC([C@@H]2C[C@H]2N)=C(OCC3=CC=CC=C3)C(F)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for S 2101

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 15.59 50
DMSO 31.18 100

制备储备液 for S 2101

以下数据基于产品分子量 311.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.04 mL 32.08 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.6 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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参考文献 for S 2101

参考文献是支持产品生物活性的出版物。

Mimasu et al (2010) Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 49 6494 PMID: 20568732

If you know of a relevant reference for S 2101, please let us know.

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关键词: S 2101, S 2101 supplier, S2101, LSD1, inhibitors, inhibits, histones, demethylases, KDM1, Histone, Demethylases, 5714, Tocris Bioscience

1 篇 S 2101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 S 2101 的部分引用包括：

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386

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S 2101 的评论

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Epigenetics Scientific Review

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