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(S)-3,4-DCPG

Cat. No. 1302 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective mGlu8a agonist
别名： UBP 1109
化学名： (S)-3,4-Dicarboxyphenylglycine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (S)-3,4-DCPG

(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo.

Caged (S)-3,4-DCPG, Racemate and R-enantiomer also available.

技术数据 for (S)-3,4-DCPG

分子量 239.18
公式 C10H9NO6
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 201730-11-2
PubChem ID 16062593
InChI Key IJVMOGKBEVRBPP-ZETCQYMHSA-N
Smiles N[C@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-3,4-DCPG

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 23.92 100
DMSO 5.98 25

制备储备液 for (S)-3,4-DCPG

以下数据基于产品分子量 239.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.9 mL 41.81 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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产品说明书 for (S)-3,4-DCPG

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (S)-3,4-DCPG

参考文献是支持产品生物活性的出版物。

Linden et al (2003) Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology 45 473 PMID: 12907308

Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732 PMID: 11311902

Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111 PMID: 9455991

Thomas et al (2001) (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 40 311 PMID: 11166323

If you know of a relevant reference for (S)-3,4-DCPG, please let us know.

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关键词: (S)-3,4-DCPG, (S)-3,4-DCPG supplier, Potent, selective, mGlu8a, agonists, Group, III, Receptors, mGlu8R, Glutamate, Metabotropic, UBP1109, UBP, 1109, (Metabotropic), 1302, Tocris Bioscience

1 篇 (S)-3,4-DCPG 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-3,4-DCPG 的部分引用包括：

Broadstock et al (2012) Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol 165 1034 PMID: 21627638

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