(S)-(-)-Bay K 8644

Cat. No. 1546 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ca_V1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644

化学名： (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is a L-type Ca²⁺-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

化合物库 for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (S)-(-)-Bay K 8644

分子量	356.3
公式	C₁₆H₁₅F₃N₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	98625-26-4
PubChem ID	6603728
InChI Key	ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@H]1[C@]2=CC=CC=C2C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-(-)-Bay K 8644

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.63	100
	ethanol	35.63	100

制备储备液 for (S)-(-)-Bay K 8644

以下数据基于产品分子量 356.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.4 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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产品说明书 for (S)-(-)-Bay K 8644

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-(-)-Bay K 8644

参考文献是支持产品生物活性的出版物。

Franckowiak et al (1985) The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 114 223 PMID: 2412855

O'Neill and Bolger (1988) Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 21 865 PMID: 2465070

Ravens and Schopper (1990) Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 341 232 PMID: 1692975

If you know of a relevant reference for (S)-(-)-Bay K 8644, please let us know.

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