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Submit Review(S)-(-)-HA-966
说明： NMDA antagonist/partial agonist
化学名： (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one
纯度： ≥98% (HPLC)
生物活性 for (S)-(-)-HA-966
(S)-(-)-HA-966 is an possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.
R-enantiomer also available.
技术数据 for (S)-(-)-HA-966
| 分子量 | 116.12 |
| 公式 | C4H8N2O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 111821-58-0 |
| PubChem ID | 183351 |
| InChI Key | HCKUBNLZMKAEIN-VKHMYHEASA-N |
| Smiles | N[C@H]1CCN(O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (S)-(-)-HA-966
参考文献 for (S)-(-)-HA-966
参考文献是支持产品生物活性的出版物。
Grobaski et al (1997) Responses of rat substantia nigra DA-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575 PMID: 9051293
Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra DA neurons through a non-N-MthD.-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387 PMID: 1578355
Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-MthD.-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347 PMID: 2153294
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关键词: (S)-(-)-HA-966, (S)-(-)-HA-966 supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, 0282, Tocris Bioscience
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