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(S)-(+)-Rolipram

Cat. No. 1350 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1350 has been discontinued.

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说明： PDE4 inhibitor. Less active enantiomer of rolipram (Cat. No. 0905)
化学名： (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for (S)-(+)-Rolipram

Less active enantiomer of the PDE4 inhibitor Rolipram.

Racemate and R-enantiomer also available.

技术数据 for (S)-(+)-Rolipram

分子量 275.35
公式 C16H21NO3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 85416-73-5
PubChem ID 158758
InChI Key HJORMJIFDVBMOB-GFCCVEGCSA-N
Smiles O=C1NC[C@H](C2=CC(OC3CCCC3)=C(OC)C=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (S)-(+)-Rolipram

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (S)-(+)-Rolipram

参考文献是支持产品生物活性的出版物。

Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147 PMID: 9681571

Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53 PMID: 9337850

Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105 PMID: 3019721

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关键词: (S)-(+)-Rolipram, (S)-(+)-Rolipram supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, 1350, Tocris Bioscience

4 篇 (S)-(+)-Rolipram 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-(+)-Rolipram 的部分引用包括：

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333

Meyer et al (2012) Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. Int J Nanomedicine 7 2449 PMID: 22654517

Brancaleone et al (2014) Annexin A1 mediates hydrogen sulfide properties in the control of inflammation. J Pharmacol Exp Ther 351 96 PMID: 25077524

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. J Biol Chem 171 2385 PMID: 24467222

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