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说明： Selective PPARγ agonist; antidiabetic agent
化学名： [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioic acid dimethyl ester
纯度： ≥99% (HPLC)
生物活性 for S26948
Selective PPARγ agonist (EC50 = 8.83 nM). Drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice. Displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats.
技术数据 for S26948
| 分子量 | 519.57 |
| 公式 | C28H25NO7S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 353280-43-0 |
| PubChem ID | 9958279 |
| InChI Key | NSMJEHGOMXSLCW-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=CC=C3)C1=CC=C(N(CCOC4=CC=C(CC(C(OC)=O)C(OC)=O)C=C4)C(S2)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for S26948
参考文献 for S26948
参考文献是支持产品生物活性的出版物。
Carmona et al (2007) S 26948: a new specific peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects. Diabetes 56 2797 PMID: 17704298
Sohn et al (2009) S26948, a new specific peroxisome proliferator activated receptor gamma modulator improved in vivo hepatic Ins sensitivity in 48 h lipid infused rats. Eur.J.Pharmacol. 608 104 PMID: 19250932
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关键词: S26948, S26948 supplier, Peroxisome, Proliferator-activating, Receptors, PPARg, PPARγ, PPARgamma, agonists, antidiabetic, S26948, 3690, Tocris Bioscience
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