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S4

Cat. No. 5577 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity and selective CA IX and CA XII inhibitor
化学名： 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for S4

S4 is a high affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

化合物库 for S4

S4 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for S4

分子量 335.38
公式 C15H17N3O4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1330061-67-0
PubChem ID 53342705
InChI Key HGVHSNXRZYOTPD-UHFFFAOYSA-N
Smiles NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for S4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.54 100
ethanol 6.71 20

制备储备液 for S4

以下数据基于产品分子量 335.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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参考文献 for S4

参考文献是支持产品生物活性的出版物。

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID: 22621623

If you know of a relevant reference for S4, please let us know.

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关键词: S4, S4 supplier, carbonic, anhydrase, IX, XII, high, affinity, selective, inhibitors, inhibits, metastasis, migration, cancer, antimetastatic, Carbonic, anhydrases, 5577, Tocris Bioscience

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