SA 4503 dihydrochloride

Cat. No. 4951 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective σ1 receptor agonist

化学名： 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SA 4503 dihydrochloride

SA 4503 dihydrochloride is a selective σ1 receptor agonist (IC₅₀ = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.

化合物库 for SA 4503 dihydrochloride

SA 4503 dihydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SA 4503 dihydrochloride

分子量	441.43
公式	C₂₃H₃₂N₂O₂.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	165377-44-6
PubChem ID	9954941
InChI Key	XWOXAKBQEMQMFH-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=CC(CCN2CCN(CCCC3=CC=CC=C3)CC2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SA 4503 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	44.14	100
	DMSO	8.83	20

制备储备液 for SA 4503 dihydrochloride

以下数据基于产品分子量 441.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for SA 4503 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SA 4503 dihydrochloride

参考文献是支持产品生物活性的出版物。

Ruscher et al (2011) The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134 732 PMID: 21278085

Matsuno et al (1996) Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur.J.Pharmacol. 306 271 PMID: 8813641

Tagashira et al (2013) Stimulation of s1-receptor restores abnormal mitochondrial Ca²⁺ mobilization and ATP production following cardiac hypertrophy. Biochim.Biophys.Acta 1830 3082 PMID: 23298811

Lever et al (2006) σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse 59 350 PMID: 16463398

If you know of a relevant reference for SA 4503 dihydrochloride, please let us know.

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关键词: SA 4503 dihydrochloride, SA 4503 dihydrochloride supplier, SA4503, dihydrochloride, selective, agonists, sigma1, receptor, σ1, Sigma1, Receptors, 4951, Tocris Bioscience

1 篇 SA 4503 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SA 4503 dihydrochloride 的部分引用包括：

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

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