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说明： Potent FAAH inhibitor
化学名： 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester
纯度： ≥99% (HPLC)
生物活性 for SA 57
SA 57 is a potent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 <10 nM). Also inhibits MAGL at higher concentrations (IC50 values are 410 nM and 1.4 μM respectively). Inhibits both human and mouse FAAH enzymes. Exhibits inhibitory activity against FAAH, MAGL and ABHD6 in vivo.
技术数据 for SA 57
| 分子量 | 338.83 |
| 公式 | C17H23ClN2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1346169-63-8 |
| PubChem ID | 44589122 |
| InChI Key | JFSSVCSHPDLFCM-UHFFFAOYSA-N |
| Smiles | ClC(C=C2)=CC=C2CCC1CCN(C(OCC(NC)=O)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SA 57
参考文献 for SA 57
参考文献是支持产品生物活性的出版物。
Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 3 418 PMID: 22860211
Owens et al (2016) Discriminative stimulus properties of the endocannabinoid catabolic enzyme inhibitor SA-57 in mice. J.Pharmacol.Exp.Ther 358 306 PMID: 27307500
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关键词: SA 57, SA 57 supplier, SA57, FAAH, fatty, acid, amide, hydrolase, inhibitors, inhibits, potent, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, 4752, Tocris Bioscience
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