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Submit ReviewSAG 21k
说明： Hedgehog signaling activator; brain penetrant and orally bioavailable
化学名： 3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for SAG 21k
SAG 21k is a potent Hedgehog signaling activator (EC50 = 0.4 nM). Orally bioavailable and brain penetrant.
化合物库 for SAG 21k
SAG 21k is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SAG 21k
| 分子量 | 556.07 |
| 公式 | C29H28ClF2N3O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 946002-48-8 |
| PubChem ID | 16678532 |
| InChI Key | YVIFQUJDZSAFKG-UHFFFAOYSA-N |
| Smiles | COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SAG 21k
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 55.61 | 100 | |
| ethanol | 11.12 | 20 |
制备储备液 for SAG 21k
以下数据基于产品分子量 556.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 8.99 mL | 17.98 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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产品说明书 for SAG 21k
参考文献 for SAG 21k
参考文献是支持产品生物活性的出版物。
Brunton et al (2009) Potent agonists of the Hedgehog signaling pathway. Bioorg.Med.Chem.Lett. 19 4308 PMID: 19500978
If you know of a relevant reference for SAG 21k, please let us know.
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关键词: SAG 21k, SAG 21k supplier, SAG21k, Hedgehog, Hh, signaling, activators, activation, orally, bioavailable, brain, penetrant, potent, Signaling, 5282, Tocris Bioscience
3 篇 SAG 21k 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SAG 21k 的部分引用包括：
Norris et al (2023) Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration Nat Commun 14 3766 PMID: 37355632
M et al (2021) Hedgehog signaling promotes endoneurial fibroblast migration and Vegf-A expression following facial nerve injury. Brain Res 1751 147204 PMID: 33189691
Olivier et al (2022) Paraxial mesoderm organoids model development of human somites. Elife 11 PMID: 35088712
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.