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Submit ReviewSAH-EZH2
说明： EZH2/EDD interaction inhibitor; suppresses PCR2 complex function
生物活性 for SAH-EZH2
SAH-EZH2 is an EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
许可信息
Sold under license from Dana-Farber Cancer Institute
技术数据 for SAH-EZH2
| 分子量 | 3432.05 |
| 公式 | C155H256N48O40 |
| 序列 |
FSSNRXKILXRTQILNQEWKQRRIQPV (Modifications: Phe-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond) |
| 储存 | Store at -20°C |
| CAS Number | 1453222-26-8 |
| Smiles | [H][C@]([C@H](O)C)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)C(C)C)=O)=O)CCC(N)=O)=O)[H])=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C)C)=O)[H])=O)CCC(N)=O)=O)NC([C@@H](NC([C@@]4(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC5=CC=CC=C5)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(N)=N)=O)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N4)=O)CC(C)C)=O)[H])=O)CCCCN)=O)C)C)=O)CCCNC(N)=N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SAH-EZH2
参考文献 for SAH-EZH2
参考文献是支持产品生物活性的出版物。
Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat.Chem.Biol. 9 643 PMID: 23974116
Kim et al (2015) SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat.Med. 21 1491 PMID: 26552009
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关键词: SAH-EZH2, SAH-EZH2 supplier, EZH2, lysine, methyltransferase, EPP, interaction, inhibitors, inhibits, stapled, peptide, PCR2, complex, methylation, Stapled, Peptides, 6708, Tocris Bioscience
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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