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Submit ReviewSalmeterol xinafoate
说明： Long-acting β2 agonist; bronchodilator
化学名： 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt
纯度： ≥99% (HPLC)
生物活性 for Salmeterol xinafoate
Salmeterol xinafoate is a long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).
化合物库 for Salmeterol xinafoate
Salmeterol xinafoate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Salmeterol xinafoate
| 分子量 | 603.75 |
| 公式 | C25H37NO4.C11H8O3 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 94749-08-3 |
| PubChem ID | 56801 |
| InChI Key | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
| Smiles | OC(C2=CC(CO)=C(O)C=C2)CNCCCCCCOCCCCC1=CC=CC=C1.OC4=C(C(O)=O)C=CC3=CC=CC=C34 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Salmeterol xinafoate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 60.37 | 100 | |
| ethanol | 12.07 | 20 |
制备储备液 for Salmeterol xinafoate
以下数据基于产品分子量 603.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.28 mL | 16.56 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
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产品说明书 for Salmeterol xinafoate
参考文献 for Salmeterol xinafoate
参考文献是支持产品生物活性的出版物。
Akabane et al (2006) Effects of salme. xinafoate and flutic. propionate on immunological activation of human cultured mast cells. Allergol.Int. 55 387 PMID: 17130681
Rennard et al (2001) Use of a long-acting inhaled beta2-adrenergic agonist, salme. xinafoate, in patients with chronic obstructive pulmonary disease. Am.J.Respir.Crit.Care Med. 163 1087 PMID: 11316640
Roberts et al (1999) The long-acting beta2-agonist salme. xinafoate: effects on airway inflammation in asthma. Eur.Respir.J. 14 275 PMID: 10515401
If you know of a relevant reference for Salmeterol xinafoate, please let us know.
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关键词: Salmeterol xinafoate, Salmeterol xinafoate supplier, long, acting, beta2, b2, β2, adrenergics, adrenoceptors, agonists, LABAs, asthma, COPD, respiratory, disease, bronchodilators, Adrenergic, Beta-2, Receptors, 4712, Tocris Bioscience
8 篇 Salmeterol xinafoate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Salmeterol xinafoate 的部分引用包括：
Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672 PMID: 21883146
Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209
Scola et al (2009) The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol 158 267 PMID: 19371332
Israël-Assayag et al (2015) ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas. Nat Commun 10 e0120095 PMID: 25799096
Pon et al (2016) The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J 30 1144 PMID: 26578688
Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319
C et al (2007) Effect of indacaterol, a novel long-acting beta2-agonist, on isolated human bronchi. Eur Respir J 29 575-81 PMID: 17135231
Nackley et al (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128 199 PMID: 17084978
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.