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说明： Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity
化学名： N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
纯度： ≥98% (HPLC)
生物活性 for SANT-1
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.
For more information about how SANT-1 may be used, see our protocol: Generation of β cells from hPSCs
化合物库 for SANT-1
SANT-1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SANT-1
| 分子量 | 373.5 |
| 公式 | C23H27N5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 304909-07-7 |
| PubChem ID | 6878030 |
| InChI Key | FOORCIAZMIWALX-JJIBRWJFSA-N |
| Smiles | CC1=NN(C(C)=C1\C=N\N1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SANT-1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 18.68 | 50 |
制备储备液 for SANT-1
以下数据基于产品分子量 373.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.35 mL | 26.77 mL | 53.55 mL |
| 2.5 mM | 1.07 mL | 5.35 mL | 10.71 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.35 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.07 mL |
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产品说明书 for SANT-1
参考文献 for SANT-1
参考文献是支持产品生物活性的出版物。
Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci.USA. 99 1407
If you know of a relevant reference for SANT-1, please let us know.
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关键词: SANT-1, SANT-1 supplier, inhibitors, inhibits, hedgehog, Hh, signaling, antagonizes, smoothened, activity, Signaling, Signalling, Smo, Receptors, antagonist, Hedgehog, Smoothened, Organoids, 1974, Tocris Bioscience
10 篇 SANT-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SANT-1 的部分引用包括：
Hoch et al (2015) MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J 29 1817 PMID: 25636740
Atwood et al (2013) GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas. Stem Cell Reports 494 484 PMID: 23446420
Strating et al (2015) Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep 10 600 PMID: 25640182
Fleury et al (2016) Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep 6 23479 PMID: 27010359
Wang et al (2012) Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol 19 972 PMID: 22921064
Yung et al (2019) Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat.Commun. 10 4647 PMID: 31604927
Yuan et al (2016) Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun 21 11024 PMID: 26996322
Nostro et al (2015) Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Neuropsychopharmacology 4 591 PMID: 25843049
Sambathkumar et al (2018) Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS One 13 e0197046 PMID: 29750821
Krentz et al (2017) Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell 41 129 PMID: 28441528
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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