SAR 216471 hydrochloride

Name: SAR 216471 hydrochloride
Brand: Tocris Bioscience
SKU: 5650

Cat. No. 5650 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5650 has been discontinued.

View all Purinergic (P2Y) Receptors products.

说明： Potent P2Y₁₂ antagonist; orally available

化学名： 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for SAR 216471 hydrochloride

SAR 216471 hydrochloride is a potent P2Y₁₂ antagonist (IC₅₀ = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.

技术数据 for SAR 216471 hydrochloride

分子量	599.51
公式	C₂₈H₃₁ClN₈O₃.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1279829-64-9
PubChem ID	70926954
InChI Key	UQLWHBMSQKUYAI-UHFFFAOYSA-N
Smiles	ClC1=CC=C2C(C(C(NC3=CC=C(N4C(C)=C(C(CCC)=O)C=N4)N=N3)=O)=CN2CC(N5CCN(C)CC5)=O)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SAR 216471 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SAR 216471 hydrochloride

参考文献是支持产品生物活性的出版物。

Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638

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Purinergic (P2Y) Receptors

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1 篇 SAR 216471 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SAR 216471 hydrochloride 的部分引用包括：

Liu et al (2018) Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Sci Rep 8 11380 PMID: 30038283