Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Name: Sar-[D-Phe 8 ]-des-Arg 9 -Bradykinin
Brand: Tocris Bioscience
SKU: 3230

Cat. No. 3230 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3230 has been discontinued.

View all Bradykinin Receptors products.

说明： Potent and selective B₁ agonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin is a potent and selective bradykinin B₁ receptor agonist (EC₅₀ = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.

技术数据 for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

分子量	975.11
公式	C₄₇H₆₆N₁₂O₁₁
序列	XRPPGFSPF (Modifications: X = Sar, Phe-9 = D-Phe)
储存	Desiccate at -20°C
CAS Number	126959-88-4
PubChem ID	164234
InChI Key	YIUBSFCQATYQJB-VCMDLEIESA-N
Smiles	[H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin

参考文献是支持产品生物活性的出版物。

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg⁹-Bradykinin and metabolically protected agonists of B¹ receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280

Drapeau et al (1993) Development and in vivo evaluation of metabolically resistant antagonists of B₁ receptors for kinins. J.Pharmacol.Exp.Ther. 266 192 PMID: 8392550

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727

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关键词: Sar-[D-Phe8]-des-Arg9-Bradykinin, Sar-[D-Phe8]-des-Arg9-Bradykinin supplier, Potent, selective, B1, agonists, Receptors, Bradykinin, 3230, Tocris Bioscience

篇 Sar-[D-Phe⁸]-des-Arg⁹-Bradykinin 的引用文献

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