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Submit ReviewSB 205607 dihydrobromide
说明： Selective, high affinity non-peptide δ1 agonist
别名： TAN 67
化学名： (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
纯度： ≥97% (HPLC)
生物活性 for SB 205607 dihydrobromide
The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).
许可信息
Sold under license
化合物库 for SB 205607 dihydrobromide
SB 205607 dihydrobromide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 205607 dihydrobromide
| 分子量 | 506.28 |
| 公式 | C23H24N2O.2HBr |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 1217628-73-3 |
| PubChem ID | 56972161 |
| InChI Key | GWXFBFMLKRAWEU-YJKXCHRFSA-N |
| Smiles | [H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 205607 dihydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 50.63 | 100 | |
| DMSO | 50.63 | 100 |
制备储备液 for SB 205607 dihydrobromide
以下数据基于产品分子量 506.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.88 mL | 19.75 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.95 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for SB 205607 dihydrobromide
参考文献 for SB 205607 dihydrobromide
参考文献是支持产品生物活性的出版物。
Kamei et al (1995) Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 276 131 PMID: 7781682
Knap et al (1995) Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 291 129 PMID: 8566162
Nagase et al (2001) The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 68 2227 PMID: 11358331
Nagase et al (1994) Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol. 64 Suppl. 1, 35P
If you know of a relevant reference for SB 205607 dihydrobromide, please let us know.
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关键词: SB 205607 dihydrobromide, SB 205607 dihydrobromide supplier, δ1-opioid, delta1-opioid, selective, high, affinity, non-peptide, agonists, DOP, Receptors, OP1, SB205607, dihydrobromide, TAN67, TAN, 67, Delta, Opioid, 0921, Tocris Bioscience
2 篇 SB 205607 dihydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 205607 dihydrobromide 的部分引用包括：
Robins et al (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry 9 112 PMID: 29686629
Nielsen et al (2012) The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol 17 224 PMID: 21309957
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