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SB 216641 hydrochloride

Cat. No. 1242 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective h5-HT1B antagonist
化学名： N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 216641 hydrochloride

SB 216641 hydrochloride is a selective h5-HT1B antagonist with approximately 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types.

许可信息

Sold with the permission of GlaxoSmithKline

技术数据 for SB 216641 hydrochloride

分子量 523.03
公式 C28H30N4O4.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 193611-67-5
PubChem ID 10392025
InChI Key JPBMDMNORXKGHZ-UHFFFAOYSA-N
Smiles Cl.COC1=C(OCCN(C)C)C=C(NC(=O)C2=CC=C(C=C2)C2=CC=C(C=C2C)C2=NOC(C)=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 216641 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 26.15 50

制备储备液 for SB 216641 hydrochloride

以下数据基于产品分子量 523.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.82 mL 19.12 mL 38.24 mL
2.5 mM 0.76 mL 3.82 mL 7.65 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

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产品说明书 for SB 216641 hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SB 216641 hydrochloride

参考文献是支持产品生物活性的出版物。

Hagan et al (1997) Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur.J.Pharmacol. 331 169 PMID: 9274976

Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 312 PMID: 930567

Schlicker et al (1997) Effects of selective h5-HT1B (SB-216641) and 5-HT1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch.Pharmacol. 356 321 PMID: 9303568

If you know of a relevant reference for SB 216641 hydrochloride, please let us know.

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关键词: SB 216641 hydrochloride, SB 216641 hydrochloride supplier, Selective, h5-HT1B, antagonist, Serotonin, Receptors, SB216641, hydrochloride, GlaxoSmithKline, GSK, 5-HT1B, 1242, Tocris Bioscience

5 篇 SB 216641 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 216641 hydrochloride 的部分引用包括：

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. J Biol Chem 19 1915 PMID: 19056862

Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902 PMID: 23087410

Dunbar et al (2010) Endogenous extracellular serotonin modulates the spinal locomotor network of the neonatal mouse. J Physiol 588 139 PMID: 19884315

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SB 216641 hydrochloride 的评论

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Excellent product.
By Anonymous on 06/03/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： CHO

1µM

After reaching 80% confluence, cells were treated with the selective 5-HT2CR antagonist SB242084 (300nM) or the 5-HT1BR antagonist SB216641 (1µM), applied 10 minutes prior to agonist application.

PMID: 26802567 参考文献
review image

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