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Submit ReviewSB 268262
Discontinued Product
4314 has been discontinued.
View all Calcitonin and Related Receptors products.
说明： Selective non-peptide CGRP antagonist
化学名： N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
纯度： ≥99% (HPLC)
生物活性 for SB 268262
SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
许可信息
Sold with the permission of GlaxoSmithKline.
技术数据 for SB 268262
| 分子量 | 401.46 |
| 公式 | C18H15N3O4S2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 217438-17-0 |
| PubChem ID | 6918567 |
| InChI Key | YXHLPJQQPOMPGE-UHFFFAOYSA-N |
| Smiles | O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SB 268262
参考文献 for SB 268262
参考文献是支持产品生物活性的出版物。
Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768 PMID: 11181905
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关键词: SB 268262, SB 268262 supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Calcitonin, and, Related, Receptors, 4314, Tocris Bioscience
1 篇 SB 268262 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 268262 的部分引用包括：
Matthias et al (2021) Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes. Front Immunol 12 722884 PMID: 34512650
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.