SB 277011A dihydrochloride

Cat. No. 4207 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective D₃ antagonist

化学名： N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 277011A dihydrochloride

SB 277011A dihydrochloride is a selective dopamine D₃ receptor antagonist (pK_i values are 8.0, 6.0, 5.0 and <5.2 for D₃, D₂, 5-HT_1D and 5-HT_1B respectively). Brain penetrant.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for SB 277011A dihydrochloride

分子量	511.49
公式	C₂₈H₃₀N₄O.2HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1226917-67-4
PubChem ID	75358288
InChI Key	HEZIOTGUXSPDAK-UHFFFAOYSA-N
Smiles	O=C(N[C@@H]3CC[C@@H](CCN4CC(C=CC(C#N)=C5)=C5CC4)CC3)C1=C2C(C=CC=C2)=NC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 277011A dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.57	50

制备储备液 for SB 277011A dihydrochloride

以下数据基于产品分子量 511.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.91 mL	19.55 mL	39.1 mL
2.5 mM	0.78 mL	3.91 mL	7.82 mL
5 mM	0.39 mL	1.96 mL	3.91 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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产品说明书 for SB 277011A dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 277011A dihydrochloride

参考文献是支持产品生物活性的出版物。

Reavill et al (2000) Pharmacological actions of a novel, high-affinity, and selective human DA D₃ receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 294 1154 PMID: 10945872

Stemp et al (2000) Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe J.Med.Chem. 43 1878 PMID: 10794704

If you know of a relevant reference for SB 277011A dihydrochloride, please let us know.

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关键词: SB 277011A dihydrochloride, SB 277011A dihydrochloride supplier, SB277011A, dihydrochloride, dopamine, dopaminergic, receptors, antagonists, selective, d3, D3, Receptors, 4207, Tocris Bioscience

1 篇 SB 277011A dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 277011A dihydrochloride 的部分引用包括：

Chen et al (2013) Electroacupuncture reduces cocaine-induced seizures and mortality in mice. Nat Neurosci 2013 134610 PMID: 23690833

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