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Submit ReviewSB 399885 hydrochloride
说明： Potent and selective 5-HT6 antagonist
化学名： N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for SB 399885 hydrochloride
SB 399885 hydrochloride is a potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).
化合物库 for SB 399885 hydrochloride
SB 399885 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 399885 hydrochloride
| 分子量 | 482.81 |
| 公式 | C18H21Cl2N3O4S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 402713-81-9 |
| PubChem ID | 6918649 |
| InChI Key | ATKZKAYWARYLBW-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC(Cl)=CC(NS(C2=CC(N3CCNCC3)=C(OC)C=C2)(=O)=O)=C1OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 399885 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 48.28 | 100 | |
| DMSO | 48.28 | 100 |
制备储备液 for SB 399885 hydrochloride
以下数据基于产品分子量 482.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.36 mL | 20.71 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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产品说明书 for SB 399885 hydrochloride
参考文献 for SB 399885 hydrochloride
参考文献是支持产品生物活性的出版物。
Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 1274 PMID: 17320917
Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166 PMID: 18455201
Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109 PMID: 1706979
If you know of a relevant reference for SB 399885 hydrochloride, please let us know.
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关键词: SB 399885 hydrochloride, SB 399885 hydrochloride supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB399885, hydrochloride, 3189, Tocris Bioscience
2 篇 SB 399885 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 399885 hydrochloride 的部分引用包括：
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Garfield et al (2014) Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia. J Exp Med 266 201 PMID: 24566060
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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