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SB 452533

Cat. No. 3265 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3265 has been discontinued.

View all TRPV Channels products.
说明： Potent TRPV1 antagonist
化学名： N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for SB 452533

SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.

许可信息

Sold for research purposes only under agreement from GlaxoSmithKline

技术数据 for SB 452533

分子量 376.29
公式 C18H22BrN3O
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 459429-39-1
PubChem ID 9842609
InChI Key IFJYEGJUQIBBQV-UHFFFAOYSA-N
Smiles CC1=CC(N(CC)CCNC(NC2=CC=CC=C2Br)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SB 452533

参考文献是支持产品生物活性的出版物。

Rami et al (2004) Discovery of small molecule antagonists of TRPV1. Bioorg.Med.Chem.Lett. 14 3631 PMID: 15203132

Weil et al (2005) Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8. Mol.Pharmacol. 68 518 PMID: 15911692

Bianchi et al (2007) [3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-ylurea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 323 285 PMID: 17660385

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关键词: SB 452533, SB 452533 supplier, SB452533, TRPV1, transient, receptor, potential, channels, antagonists, vanilloid, receptors, analgesic, analgaesic, TRPV, 3265, Tocris Bioscience

1 篇 SB 452533 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 452533 的部分引用包括：

Vijayvergiya et al (2015) Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers. Mol Pain 10 e0141366 PMID: 26513481

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