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SB 611812

Cat. No. 4670 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4670 has been discontinued.

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说明： Urotensin-II (UT) antagonist; attenuates cardiac dysfunction
化学名： 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for SB 611812

SB 611812 is an urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for SB 611812

分子量 491.74
公式 C17H16Cl3F3N2O3S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 345892-71-9
PubChem ID 10278166
InChI Key UIZHOFJFIOCYLH-UHFFFAOYSA-N
Smiles ClC1=CC=C(NS(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)(=O)=O)C=C1OCCN(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SB 611812

参考文献是支持产品生物活性的出版物。

Bousette et al (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27 2919 PMID: 16919371

Bousette et al (2006) Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation. J.Mol.Cell Cardiol. 41 285 PMID: 16797584

Papadopoulos et al (2008) Urotensin-II and cardiovascular remodeling. Peptides 29 764 PMID: 17988761

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关键词: SB 611812, SB 611812 supplier, SB611812, GSK, urotensin-II, urotensin, receptors, antagonists, cardiac, dysfunction, remodeling, remodelling, Urotensin-II, Receptors, 4670, Tocris Bioscience

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