SB 612111 hydrochloride

Cat. No. 3573 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective NOP antagonist

化学名： (5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

纯度： ≥97% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 612111 hydrochloride

SB 612111 hydrochloride is a selective NOP receptor antagonist (K_i values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.

许可信息

Sold with the permission of GlaxoSmithKline

化合物库 for SB 612111 hydrochloride

SB 612111 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 612111 hydrochloride

分子量	454.86
公式	C₂₄H₂₉Cl₂NO.HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
PubChem ID	21061234
InChI Key	DCKUVQADDNMWEF-DQFHVVJASA-N
Smiles	CC1=CC=CC2=C1CC[C@H](CN3CCC(C4=C(Cl)C=CC=C4Cl)CC3)C[C@@H]2O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 612111 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	45.49	100
	ethanol	22.74	50

制备储备液 for SB 612111 hydrochloride

以下数据基于产品分子量 454.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.2 mL	10.99 mL	21.98 mL
5 mM	0.44 mL	2.2 mL	4.4 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for SB 612111 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 612111 hydrochloride

参考文献是支持产品生物活性的出版物。

Zaratin et al (2004) Modification of nociception and mor. tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) J.Pharmacol.Exp.Ther. 308 454 PMID: 14593080

Rizzi et al (2007) Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies. J.Pharmacol.Exp.Ther. 321 968 PMID: 17329551

Spagnolo et al (2007) Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies. J.Pharm.Exp.Ther. 106 961

If you know of a relevant reference for SB 612111 hydrochloride, please let us know.

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关键词: SB 612111 hydrochloride, SB 612111 hydrochloride supplier, SB612111, hydrochloride, opioids, NOP, receptors, antagonists, ORL1, N/OFQ, 371980-98-2, Receptors, 3573, Tocris Bioscience

2 篇 SB 612111 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 612111 hydrochloride 的部分引用包括：

Michael R et al (2019) Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal 12 PMID: 30914485

Hardaway et al (2016) Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res 307 25 PMID: 27036650

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