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SB 657510

Cat. No. 3571 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3571 has been discontinued.

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说明： Selective urotensin-II (UT) receptor antagonist
化学名： 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for SB 657510

SB 657510 is a selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM).

许可信息

Sold with the permission of GlaxoSmithKline

技术数据 for SB 657510

分子量 505.81
公式 C19H22BrClN2O5S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 474960-44-6
PubChem ID 11272107
InChI Key KQCZCINJGIRLCD-CYBMUJFWSA-N
Smiles BrC1=CC(OC)=C(OC)C=C1S(NC2=CC=C(Cl)C(O[C@H]3CN(C)CC3)=C2)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SB 657510

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化学品安全技术说明书

参考文献 for SB 657510

参考文献是支持产品生物活性的出版物。

Douglas et al (2005) Nonpeptide urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br.J.Pharmacol. 145 620 PMID: 15852036

Behm et al (2008) Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br.J.Pharmacol. 155 374 PMID: 18587423

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关键词: SB 657510, SB 657510 supplier, SB657510, UT-II, urotensin-II, receptors, antagonists, GlaxoSmithKline, Urotensin-II, Receptors, 3571, Tocris Bioscience

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