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SB 674042

Cat. No. 4673 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective non-peptide OX1 antagonist
化学名： [5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 674042

SB 674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for SB 674042

分子量 448.51
公式 C24H21FN4O2S
储存 Store at +4°C
CAS Number 483313-22-0
PubChem ID 10204153
InChI Key HYBZWVLPALMACV-KRWDZBQOSA-N
Smiles O=C(C2=C(C5=CC=CC=C5F)SC(C)=N2)N1[C@H](CC3=NN=C(C4=CC=CC=C4)O3)CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 674042

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.85 100
ethanol 44.85 100

制备储备液 for SB 674042

以下数据基于产品分子量 448.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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参考文献 for SB 674042

参考文献是支持产品生物活性的出版物。

Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340 PMID: 14691055

Ellis et al (2006) Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Biol.Chem. 281 38812 PMID: 17015451

If you know of a relevant reference for SB 674042, please let us know.

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关键词: SB 674042, SB 674042 supplier, Potent, selective, non, peptide, OX1, receptors, antagonists, orexin1, orexin-1, SB674042, Receptor, 4673, Tocris Bioscience

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