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Submit ReviewSB 699551
说明： Selective 5-ht5a antagonist
化学名： N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for SB 699551
SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for SB 699551
| 分子量 | 584.66 |
| 公式 | C34H45N3O.2HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 864741-95-7 |
| PubChem ID | 11983346 |
| InChI Key | QJMKBIHLMPTYTI-UHFFFAOYSA-N |
| Smiles | O=C(CCC4CCCC4)N(CCN(C)C)CC(C=C2)=CC=C2C1=CC=C(CNCCC3=CC=CC=C3)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 699551
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 14.62 | 25 | |
| ethanol | 5.85 | 10 |
制备储备液 for SB 699551
以下数据基于产品分子量 584.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.84 mL | 34.21 mL | 68.42 mL |
| 1.25 mM | 1.37 mL | 6.84 mL | 13.68 mL |
| 2.5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 12.5 mM | 0.14 mL | 0.68 mL | 1.37 mL |
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产品说明书 for SB 699551
参考文献 for SB 699551
参考文献是支持产品生物活性的出版物。
Thomas et al (2006) SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an auto Neuropharmacology 51 566 PMID: 16846620
Thomas (2006) 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 111 707 PMID: 16516972
Corbett et al (2005) Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 15 4014 PMID: 16002289
If you know of a relevant reference for SB 699551, please let us know.
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关键词: SB 699551, SB 699551 supplier, Selective, 5-ht5A, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB699551, GlaxoSmithKline, GSK, 5-ht5, 3188, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.