5-ht5 Receptors
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents and humans.
5-ht5 Receptor Antagonists |
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|---|---|
| Cat. No. | 产品名称/活性 |
| 3188 | SB 699551 |
| Selective 5-ht5a antagonist | |
Other |
|
| Cat. No. | 产品名称/活性 |
| 0458 | 5-Carboxamidotryptamine maleate |
| Has high affinity for 5-ht5A and 5-HT7. Also 5-HT1 agonist | |
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents and humans. mRNA for the human ortholog of the 5-ht5a receptor has been found in human cerebral cortex, hippocampus, and cerebellar tissue, and in vitro studies have shown functional G protein coupling of the 5-ht5a receptor upon ligand binding. A potential role in mood, cognitive function, circadian rhythm and shizophrenia has been suggested for the 5-ht5a receptor. A functional transcript of the 5-ht5b receptor has not yet been identified in humans.
External sources of pharmacological information for 5-ht5 Receptors :
Literature for 5-ht5 Receptors
Tocris offers the following scientific literature for 5-ht5 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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