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SB 706375

Cat. No. 4667 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4667 has been discontinued.

View all Urotensin-II Receptors products.
说明： High affinity, non-peptide UT receptor antagonist
化学名： 2-Bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for SB 706375

SB 706375 is a high affinity, non-peptide antagonist of the urotensin-II (UT) receptor. Exhibits high affinity for mammalian UT receptors, including human, mouse and rat (Ki values are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). Also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Displays ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for SB 706375

分子量 539.36
公式 C20H22BrF3N2O5S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 733734-61-7
PubChem ID 21023902
InChI Key BPOWQJYAMDEAFF-CYBMUJFWSA-N
Smiles BrC1=CC(OC)=C(OC)C=C1S(NC2=CC=C(C(F)(F)F)C(O[C@H]3CN(C)CC3)=C2)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SB 706375

参考文献是支持产品生物活性的出版物。

Douglas et al (2005) Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br.J.Pharmacol. 145 620 PMID: 15852036

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关键词: SB 706375, SB 706375 supplier, SB706375, urotensin-II, U-II, receptors, UT, antagonists, high, affinity, Urotensin-II, Receptors, 4667, Tocris Bioscience

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