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Submit ReviewSB 706504
说明： p38 MAPK inhibitor
化学名： N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine
纯度： ≥98% (HPLC)
生物活性 for SB 706504
SB 706504 is a p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Effects on suppression of LPS-induced gene and protein expression are enhanced in combination with dexamethasone (Cat. No. 1126).
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
化合物库 for SB 706504
SB 706504 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 706504
| 分子量 | 492.46 |
| 公式 | C24H19F3N8O |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 911110-38-8 |
| PubChem ID | 11853799 |
| InChI Key | ZQFBVJBAWLZLOM-UHFFFAOYSA-N |
| Smiles | N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 706504
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 49.25 | 100 |
制备储备液 for SB 706504
以下数据基于产品分子量 492.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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产品说明书 for SB 706504
参考文献 for SB 706504
参考文献是支持产品生物活性的出版物。
Kent et al (2009) Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexameth. and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl) J.Pharmacol.Exp.Ther. 328 458 PMID: 19004925
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关键词: SB 706504, SB 706504 supplier, SB706504, p38, MAPK, inhibitors, map, kinases, inhibits, dexamethasone, inflammatory, cytokines, 5040, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SB 706504
