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Submit ReviewSC 26196
说明： Selective fatty acid desaturase 2 inhibitor
化学名： α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
纯度： ≥98% (HPLC)
生物活性 for SC 26196
SC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for SC 26196
SC 26196 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SC 26196
| 分子量 | 423.55 |
| 公式 | C27H29N5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 218136-59-5 |
| PubChem ID | 9845201 |
| InChI Key | QFYKXKMYVYOUNJ-JBASAIQMSA-N |
| Smiles | N#CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCCN1CCN(/N=C/C2=CN=CC=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SC 26196
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.59 | 25 |
制备储备液 for SC 26196
以下数据基于产品分子量 423.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.44 mL | 47.22 mL | 94.44 mL |
| 1.25 mM | 1.89 mL | 9.44 mL | 18.89 mL |
| 2.5 mM | 0.94 mL | 4.72 mL | 9.44 mL |
| 12.5 mM | 0.19 mL | 0.94 mL | 1.89 mL |
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产品说明书 for SC 26196
参考文献 for SC 26196
参考文献是支持产品生物活性的出版物。
Obukowicz et al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157 PMID: 9765335
Hansen-Petrik et al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157 PMID: 11741743
Zhang et al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169 PMID: 20086206
Li et al (2017) Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 20 1 PMID: 28041894
If you know of a relevant reference for SC 26196, please let us know.
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关键词: SC 26196, SC 26196 supplier, Pfizer, SC26196, desaturases, delta6, d6, Δ6, selective, inhibitors, inhibits, anti-inflammatory, fatty, acid, metabolism, Other, Lipid, Metabolism, Cancer, Stem, Cells, Oxygenases/Oxidases, 4189, Tocris Bioscience
2 篇 SC 26196 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SC 26196 的部分引用包括：
Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. PLoS One 12 109 PMID: 26656090
Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839
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