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SC 560

Cat. No. 1550 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cyclooxygenase-1 (COX-1) inhibitor
化学名： 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SC 560

SC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

技术数据 for SC 560

分子量 352.74
公式 C17H12ClF3N2O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 188817-13-2
PubChem ID 4306515
InChI Key PQUGCKBLVKJMNT-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)N1N=C(C=C1C1=CC=C(Cl)C=C1)C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SC 560

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.27 100
ethanol 8.82 25

制备储备液 for SC 560

以下数据基于产品分子量 352.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for SC 560

参考文献是支持产品生物活性的出版物。

Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735 PMID: 15867369

Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475 PMID: 15974942

Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313 PMID: 9789085

If you know of a relevant reference for SC 560, please let us know.

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关键词: SC 560, SC 560 supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, SC560, 1550, Tocris Bioscience

1 篇 SC 560 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SC 560 的部分引用包括：

Fritz et al (2016) Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest 126 695 PMID: 26690700

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SC 560 的评论

平均评分: 5 (Based on 1 Review.)

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a COX-1 inhibitor.
By Anonymous on 02/01/2018
分析类型： Ex Vivo
种属： Rat

It is a higly lipophilic COX-1 inhibitor. It decreased tACPD-induced prostaglandin E2 in rat brain slice.

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