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Submit ReviewSC 58125
说明： Selective cyclooxygenase-2 (COX-2) inhibitor
化学名： 5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
纯度： ≥98% (HPLC)
生物活性 for SC 58125
SC 58125 is a selective cyclooxygenase 2 (COX-2) inhibitor (IC50 values are 0.04 and >100 μM for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for SC 58125
| 分子量 | 384.35 |
| 公式 | C17H12F4N2O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 162054-19-5 |
| PubChem ID | 115239 |
| InChI Key | JHBIMJKLBUMNAU-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(C)=O)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SC 58125
参考文献 for SC 58125
参考文献是支持产品生物活性的出版物。
Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810 PMID: 8663121
Williams et al (2001) A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established colon cancer xenografts. Neoplasia 3 428 PMID: 11687954
Seibert et al (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc.Natl.Acad.Sci.USA 91 12013
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关键词: SC 58125, SC 58125 supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58125, Pfizer, Cyclooxygenase, 2895, Tocris Bioscience
1 篇 SC 58125 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SC 58125 的部分引用包括：
Lee et al (2018) CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Res Ther 20 62 PMID: 29622035
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