SCH 202676 hydrobromide

Cat. No. 1400 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibitor of ligand binding to G-protein-coupled receptors

化学名： N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SCH 202676 hydrobromide

SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC₅₀ values are 0.1-1.8 μM).

化合物库 for SCH 202676 hydrobromide

SCH 202676 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SCH 202676 hydrobromide

分子量	348.26
公式	C₁₅H₁₃N₃S.HBr
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	265980-25-4
PubChem ID	9884675
InChI Key	YJYGOWVFDGULLL-UHFFFAOYSA-N
Smiles	C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SCH 202676 hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	8.71	25 温和加热

制备储备液 for SCH 202676 hydrobromide

以下数据基于产品分子量 348.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	11.49 mL	57.43 mL	114.86 mL
1.25 mM	2.3 mL	11.49 mL	22.97 mL
2.5 mM	1.15 mL	5.74 mL	11.49 mL
12.5 mM	0.23 mL	1.15 mL	2.3 mL

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产品说明书 for SCH 202676 hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SCH 202676 hydrobromide

参考文献是支持产品生物活性的出版物。

Fawzi et al (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 59 30 PMID: 11125021

Gao et al (2004) Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 74 3173 PMID: 15081581

Lewandowicz et al (2006) The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 147 422 PMID: 16402041

If you know of a relevant reference for SCH 202676 hydrobromide, please let us know.

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关键词: SCH 202676 hydrobromide, SCH 202676 hydrobromide supplier, inhibitors, inhibits, ligand, binding, G-protein-coupled, receptors, SCH202676, hydrobromide, Heterotrimeric, G-protein, GTPases, 1400, Tocris Bioscience

1 篇 SCH 202676 hydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SCH 202676 hydrobromide 的部分引用包括：

Müller et al (2018) Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation. Front Immunol 9 2520 PMID: 30450098

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