Scrambled ¹⁰Panx

Name: Scrambled 10 Panx
Brand: Tocris Bioscience
SKU: 3708

Cat. No. 3708 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3708 has been discontinued.

View all Gap Channels products.

说明： Scrambled version of ¹⁰Panx (Cat. No. 3348), Panx-1 mimetic inhibitory peptide

别名： ^scPanx

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for Scrambled ¹⁰Panx

Scrambled ¹⁰Panx is a scrambled version of ¹⁰Panx (Cat. No. 3348), a Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions, inhibits P2X₇-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. ¹⁰Panx also blocks activation of NMDA receptor secondary currents (I_2nd) by > 70%.

技术数据 for Scrambled ¹⁰Panx

分子量	1242.37
公式	C₅₈H₇₉N₁₅O₁₆
序列	FSVYWAQADR
储存	Store at -20°C
CAS Number	1315378-72-3
PubChem ID	90488872
InChI Key	VNQGVHMGXBRHRA-QZHJRRRASA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Scrambled ¹⁰Panx

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Scrambled ¹⁰Panx

参考文献是支持产品生物活性的出版物。

Pelegrin and Surprenant (2006) Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X₇ receptor. EMBO J. 25 5071 PMID: 17036048

Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431

Thompson et al (2008) Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science 322 1555 PMID: 19056988

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关键词: Scrambled 10Panx, Scrambled 10Panx supplier, Panx-1, mimetic, inhibitory, peptide, blocks, pannexin-1, gap, junctions, Connexins, Channels, modulators, scpanx, Gap, 3708, Tocris Bioscience

4 篇 Scrambled ¹⁰Panx 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Scrambled ¹⁰Panx 的部分引用包括：

Albalawi et al (2017) The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci 11 227 PMID: 28848393

Kleiner et al (2018) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis 24 647 PMID: 30310263

Hudson et al (2019) Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation. J Pharmacol Exp Ther 370 44 PMID: 31004077

Chen et al (2019) Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis. Sci Rep 9 160 PMID: 30655582