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SecinH3

Cat. No. 2849 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Sec7-specific GEF inhibitor; selective for cytohesin family
化学名： N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SecinH3

SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

化合物库 for SecinH3

SecinH3 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SecinH3

分子量 460.5
公式 C24H20N4O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 853625-60-2
PubChem ID 1029232
InChI Key QPGYAMIHXLCFTJ-UHFFFAOYSA-N
Smiles O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SecinH3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.05 100

制备储备液 for SecinH3

以下数据基于产品分子量 460.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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产品说明书 for SecinH3

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SecinH3

参考文献是支持产品生物活性的出版物。

Hafner et al (2006) Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance. Nature 444 941 PMID: 17167487

Fuss et al (2006) The cytohesin Steppke is essential for Ins signalling in Drosophila. Nature 444 945 PMID: 17167488

If you know of a relevant reference for SecinH3, please let us know.

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关键词: SecinH3, SecinH3 supplier, Sec7-specific, GEF, inhibitors, inhibits, cytohesins, hCyh2, hCyh1, mCyh3, hCyh3, drosophila, steppke, G, Proteins, Small, Arf, 2849, Tocris Bioscience

4 篇 SecinH3 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SecinH3 的部分引用包括：

Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463

Risse et al (2011) Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Pain 300 L958 PMID: 21460123

Guichard et al (2017) Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog 13 e1006603 PMID: 28945820

Abdul-Salam et al (2019) CLIC4/Arf6 Pathway. Circ Res 124 52 PMID: 30582444

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